0599 Sleep Stage Transition Patterns Among Youth with CNS Disorders of Hypersomnolence

Abstract Introduction Narcolepsy type 1 (NT1) is associated with frequent sleep stage transitions during nocturnal sleep. In this study, we report the pattern of that occurs and its relationship to CSF-orexin levels among pediatric NT1 patients. Furthermore, study patterns in patients Type 2 (NT2) Idiopathic Hypersomnia (IH). Methods We conducted a retrospective, cross-sectional polysomnograms (PSGs) cohort ages 5-21 years (n=160), NT2 (n=24), IH (n=28), subjectively sleepy controls (n=115) collected at Boston Children’s Hospital, Boston, MA University Bologna, Italy. compared between different sleep/wake stages PSG by diagnostic group as well level (low ≤110 pg/ml; normal >110 pg/ml) using chi-square testing was adjusted for multiple comparisons. Results demonstrated from wake all except N3 vs. controls, NT2, N1 less N2 The had distinct more REM N2. showed similar controls. low CSF orexin Conclusion Young have unique states. These findings are further confirmed level. exception suggesting dysregulation light stage. contrast, shows Overall, results support differing phenotypes demarcating these severe daytime sleepiness. Support (if any) National Institutes Health grant 5K23NS104267-2 K.M